Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with high heritability and
complex inheritance. In the past decade, successful identification of numerous susceptibility …

Fuchs endothelial corneal dystrophy (FECD) is a common cause for heritable visual loss in
the elderly. Since the first description of an association between FECD and common …

Applying tissue-specific deconvolution of transcriptional networks to identify their master
regulators (MRs) in neuropsychiatric disorders has been largely unexplored. Here, using …

Transcription factor 4 is a class I basic helix-loop-helix transcription factor regulating gene
expression. Altered TCF4 gene expression has been linked to non-syndromic intellectual …

Abstract Transcription factor 4 (TCF4) is a basic helix-loop-helix transcription factor that is
implicated in a variety of psychiatric disorders including autism spectrum disorder (ASD) …

Background Early stress increases the risk for psychiatric disorders. Glucocorticoids are
stress mediators that regulate transcriptional activity and morphology in the hippocampus …

Transcriptional regulatory changes in the developing and adult brain are prominent features
of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly …

A strong body of evidence supports a role for immune dysregulation across many psychiatric
disorders including depression, the leading cause of global disability. Recent progress in …

Proneural factors of the basic helix–loop–helix family coordinate neurogenesis and
neurodifferentiation. Among them, NEUROG2 and NEUROD2 subsequently act to specify …

Neurodevelopmental disorders (NDDs) are a heterogeneous and highly prevalent group of
psychiatric conditions marked by impairments in the nervous system. Their onset occurs …