Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …

The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

The field of membrane protein structural biology has been revolutionized over the last few
years with a number of high profile structures being solved using cryo-EM including Piezo …

Membrane proteins usually need to be extracted from their native environment and
separated from other membrane components for in-depth in vitro characterization. The use …

New technologies for the purification of stable membrane proteins have emerged in recent
years, in particular methods that allow the preparation of membrane proteins with their …

Biological characterisation of membrane proteins lags behind that of soluble proteins. This
reflects issues with the traditional use of detergents for extraction, as the surrounding lipids …

Lipid-bilayer nanodiscs provide a stable, native-like membrane environment for the
functional and structural studies of membrane proteins and other membrane-binding …

The shape and size of self‐assembled structures upon local organization of their molecular
building blocks are hard to predict in the presence of long‐range interactions. Combining …

The nanodisc technology is increasingly used for structural studies on membrane proteins
and drug delivery. The development of synthetic polymer nanodiscs and the recent …