[HTML][HTML] ALS genetics: gains, losses, and implications for future therapies

G Kim, O Gautier, E Tassoni-Tsuchida, XR Ma… - Neuron, 2020 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …

RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?

F Fabbiano, J Corsi, E Gurrieri… - Journal of …, 2020 - Wiley Online Library
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …

[HTML][HTML] A large-scale binding and functional map of human RNA-binding proteins

EL Van Nostrand, P Freese, GA Pratt, X Wang, X Wei… - Nature, 2020 - nature.com
Many proteins regulate the expression of genes by binding to specific regions encoded in
the genome 1. Here we introduce a new data set of RNA elements in the human genome …

Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation

P Tziortzouda, L Van Den Bosch, F Hirth - Nature Reviews …, 2021 - nature.com
Cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP43; also known as TARDBP
or TDP-43) is a key pathological feature of several neurodegenerative diseases, including …

[HTML][HTML] Sequence, structure, and context preferences of human RNA binding proteins

D Dominguez, P Freese, MS Alexis, A Su, M Hochman… - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS

X Zuo, J Zhou, Y Li, K Wu, Z Chen, Z Luo… - Nature structural & …, 2021 - nature.com
Amyotrophic lateral sclerosis (ALS) was initially thought to be associated with oxidative
stress when it was first linked to mutant superoxide dismutase 1 (SOD1). The subsequent …

Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads

AC Murthy, WS Tang, N Jovic, AM Janke… - Nature structural & …, 2021 - nature.com
The RNA-binding protein FUS (Fused in Sarcoma) mediates phase separation in
biomolecular condensates and functions in transcription by clustering with RNA polymerase …

[HTML][HTML] Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease

A Sommer, F Marxreiter, F Krach, T Fadler, J Grosch… - Cell stem cell, 2018 - cell.com
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive
degeneration of midbrain neurons (MBNs). Recent evidence suggests contribution of the …

Amyotrophic lateral sclerosis

O Hardiman, A Al-Chalabi, A Chio, EM Corr… - Nature reviews Disease …, 2017 - nature.com
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …

[HTML][HTML] Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions

JK Nussbacher, R Tabet, GW Yeo, C Lagier-Tourenne - Neuron, 2019 - cell.com
RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …