[HTML][HTML] ALS genetics: gains, losses, and implications for future therapies
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …
RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
[HTML][HTML] A large-scale binding and functional map of human RNA-binding proteins
EL Van Nostrand, P Freese, GA Pratt, X Wang, X Wei… - Nature, 2020 - nature.com
Many proteins regulate the expression of genes by binding to specific regions encoded in
the genome 1. Here we introduce a new data set of RNA elements in the human genome …
the genome 1. Here we introduce a new data set of RNA elements in the human genome …
Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation
P Tziortzouda, L Van Den Bosch, F Hirth - Nature Reviews …, 2021 - nature.com
Cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP43; also known as TARDBP
or TDP-43) is a key pathological feature of several neurodegenerative diseases, including …
or TDP-43) is a key pathological feature of several neurodegenerative diseases, including …
[HTML][HTML] Sequence, structure, and context preferences of human RNA binding proteins
D Dominguez, P Freese, MS Alexis, A Su, M Hochman… - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS
X Zuo, J Zhou, Y Li, K Wu, Z Chen, Z Luo… - Nature structural & …, 2021 - nature.com
Amyotrophic lateral sclerosis (ALS) was initially thought to be associated with oxidative
stress when it was first linked to mutant superoxide dismutase 1 (SOD1). The subsequent …
stress when it was first linked to mutant superoxide dismutase 1 (SOD1). The subsequent …
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads
The RNA-binding protein FUS (Fused in Sarcoma) mediates phase separation in
biomolecular condensates and functions in transcription by clustering with RNA polymerase …
biomolecular condensates and functions in transcription by clustering with RNA polymerase …
[HTML][HTML] Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease
A Sommer, F Marxreiter, F Krach, T Fadler, J Grosch… - Cell stem cell, 2018 - cell.com
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive
degeneration of midbrain neurons (MBNs). Recent evidence suggests contribution of the …
degeneration of midbrain neurons (MBNs). Recent evidence suggests contribution of the …
Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …
by the degeneration of both upper and lower motor neurons, which leads to muscle …
[HTML][HTML] Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions
RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
regulation of RNA processing and transport. Alterations of these proteins impact multiple …