Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

SOX2 is a transcription factor conserved throughout vertebrate evolution, whose expression
marks the central nervous system from the earliest developmental stages. In humans, SOX2 …

ABSTRACT Cajal-Retzius neurons (CRs) are among the first-born neurons in the
developing cortex of reptiles, birds and mammals, including humans. The peculiarity of CRs …

The identification of individual or clusters of predictive genetic alterations might help in
defining the outcome of cancer treatment, allowing for the stratification of patients into …

Abstract Cajal-Retzius cells (CRs) are a transient neuronal type of the developing cerebral
cortex. Over the years, they have been shown or proposed to play important functions in …

Cancer largely adheres to Darwinian selection. Evolutionary forces are prominent during
metastasis, the final and incurable disease stage, where cells acquire combinations of …

Summary The impact of Cajal-Retzius cells on the regulation of hippocampal circuits and
related behaviors is unresolved. Here, we directly address this issue by impairing the …

The transcription factor p73, a member of the p53 tumor-suppressor family, regulates cell
death and also supports tumorigenesis, although the mechanistic basis for the dichotomous …

p73, a p53 family member, undergoes alternative splicing at the 3′ end to produce multiple
isoforms, but their expression and activity are largely unknown. Thus, CRISPR was used to …