Translating kratom-drug interactions: from bedside to bench and back

RS Tanna, NB Cech, NH Oberlies, AE Rettie… - Drug Metabolism and …, 2023 - ASPET
Kratom is a botanical natural product belonging to the coffee family, with stimulant effects at
low doses and opioid-like effects at higher doses. During the last two decades, kratom has …

[HTML][HTML] An insight review on the neuropharmacological effects, mechanisms of action, pharmacokinetics and toxicity of mitragynine

NAK Annuar, UK Azlan, A Mediani, X Tong… - Biomedicine & …, 2024 - Elsevier
Mitragynine is one of the main psychoactive alkaloids in Mitragyna speciosa Korth.(kratom).
It has opium-like effects by acting on μ-, δ-, and κ-opioid receptors in the brain. The …

[HTML][HTML] Antidiabetic and antioxidant activities of Mitragyna speciosa (kratom) leaf extract in type 2 diabetic rats

P Zhang, W Wei, X Zhang, C Wen… - Biomedicine & …, 2023 - Elsevier
Mitragyna speciosa is a medicinal plant with a reputation for treating pains, diabetes as well
as increasing energy and sexual desires. However, there is no scientific evidence to validate …

[HTML][HTML] Kratom withdrawal: discussions and conclusions of a scientific expert forum

JE Henningfield, MC Chawarski… - Drug and alcohol …, 2023 - ncbi.nlm.nih.gov
Clarity on kratom's dependence and withdrawal potential increased substantially over the
past decade with increased research funding from the US National Institute on Drug Abuse …

[HTML][HTML] Lewis Acid-Catalyzed Formal (4+ 2)-Cycloaddition between Cross-Conjugated Azatrienes and Styrylmalonates: The Way to Functionalized Quinolizidine …

PG Sergeev, RA Novikov, YV Tomilov - Molecules, 2022 - mdpi.com
Quinolizidine and azaphenalene alkaloids are common in nature and exhibit a
pharmaceutical activity, which stirs up increased interest in expanding the range of methods …

Drug testing for mitragynine and kratom: Analytical challenges and medico‐legal considerations

A Helander, A Rylski - Drug Testing and Analysis, 2023 - Wiley Online Library
Mitragyna speciosa, known as kratom, is a tropical tree native to Southeast Asia that has
long been used to increase energy and in traditional medicine. Kratom leaves contain …

[HTML][HTML] Chemical, pharmacological properties and biosynthesis of opioid mitragynine in Mitragyna speciosa (kratom)

JJO Garza-Garcia, Y Qu - Current Opinion in Plant Biology, 2024 - Elsevier
Mitragynine, an alkaloid found in Mitragyna speciosa (kratom), shows promise as a potential
alternative to opioids owing to its distinctive indole alkaloid structure and its capacity for pain …

[HTML][HTML] A Chromosome-Scale Genome Assembly of Mitragyna speciosa (Kratom) and the Assessment of Its Genetic Diversity in Thailand

W Pootakham, T Yoocha, N Jomchai, W Kongkachana… - Biology, 2022 - mdpi.com
Simple Summary Mitragyna speciosa (Kratom) is a narcotic plant indigenous to Southeast
Asian countries, including Thailand. Traditionally, M. speciosa has been used as medicine …

Receptor selectivity and therapeutic potential of kratom in substance use disorders

S Mukhopadhyay, S Gupta, JL Wilkerson… - Current Addiction …, 2023 - Springer
Abstract Purpose of Review Kratom (Mitragyna speciosa Korth) contains several alkaloids,
some interacting with opioid receptors and attracting recreational use in the western world …

[HTML][HTML] RP-HPLC-DAD Analysis of Mitragynine Content in Mitragyna speciosa Korth. (Ketum) Leaf Extracts Prepared Using Ultrasound Assisted Extraction …

T Karunakaran, YS Goh, R Santhanam, V Murugaiyah… - Separations, 2022 - mdpi.com
Mitragynine and its congeners are one of the major phytoconstituents present in Mitragyna
speciosa Korth.(ketum) leaves and a well-known factor that contributes to ketum's …