Translating kratom-drug interactions: from bedside to bench and back
Kratom is a botanical natural product belonging to the coffee family, with stimulant effects at
low doses and opioid-like effects at higher doses. During the last two decades, kratom has …
low doses and opioid-like effects at higher doses. During the last two decades, kratom has …
[HTML][HTML] An insight review on the neuropharmacological effects, mechanisms of action, pharmacokinetics and toxicity of mitragynine
NAK Annuar, UK Azlan, A Mediani, X Tong… - Biomedicine & …, 2024 - Elsevier
Mitragynine is one of the main psychoactive alkaloids in Mitragyna speciosa Korth.(kratom).
It has opium-like effects by acting on μ-, δ-, and κ-opioid receptors in the brain. The …
It has opium-like effects by acting on μ-, δ-, and κ-opioid receptors in the brain. The …
[HTML][HTML] Antidiabetic and antioxidant activities of Mitragyna speciosa (kratom) leaf extract in type 2 diabetic rats
P Zhang, W Wei, X Zhang, C Wen… - Biomedicine & …, 2023 - Elsevier
Mitragyna speciosa is a medicinal plant with a reputation for treating pains, diabetes as well
as increasing energy and sexual desires. However, there is no scientific evidence to validate …
as increasing energy and sexual desires. However, there is no scientific evidence to validate …
[HTML][HTML] Kratom withdrawal: discussions and conclusions of a scientific expert forum
JE Henningfield, MC Chawarski… - Drug and alcohol …, 2023 - ncbi.nlm.nih.gov
Clarity on kratom's dependence and withdrawal potential increased substantially over the
past decade with increased research funding from the US National Institute on Drug Abuse …
past decade with increased research funding from the US National Institute on Drug Abuse …
[HTML][HTML] Lewis Acid-Catalyzed Formal (4+ 2)-Cycloaddition between Cross-Conjugated Azatrienes and Styrylmalonates: The Way to Functionalized Quinolizidine …
PG Sergeev, RA Novikov, YV Tomilov - Molecules, 2022 - mdpi.com
Quinolizidine and azaphenalene alkaloids are common in nature and exhibit a
pharmaceutical activity, which stirs up increased interest in expanding the range of methods …
pharmaceutical activity, which stirs up increased interest in expanding the range of methods …
Drug testing for mitragynine and kratom: Analytical challenges and medico‐legal considerations
A Helander, A Rylski - Drug Testing and Analysis, 2023 - Wiley Online Library
Mitragyna speciosa, known as kratom, is a tropical tree native to Southeast Asia that has
long been used to increase energy and in traditional medicine. Kratom leaves contain …
long been used to increase energy and in traditional medicine. Kratom leaves contain …
[HTML][HTML] Chemical, pharmacological properties and biosynthesis of opioid mitragynine in Mitragyna speciosa (kratom)
JJO Garza-Garcia, Y Qu - Current Opinion in Plant Biology, 2024 - Elsevier
Mitragynine, an alkaloid found in Mitragyna speciosa (kratom), shows promise as a potential
alternative to opioids owing to its distinctive indole alkaloid structure and its capacity for pain …
alternative to opioids owing to its distinctive indole alkaloid structure and its capacity for pain …
[HTML][HTML] A Chromosome-Scale Genome Assembly of Mitragyna speciosa (Kratom) and the Assessment of Its Genetic Diversity in Thailand
W Pootakham, T Yoocha, N Jomchai, W Kongkachana… - Biology, 2022 - mdpi.com
Simple Summary Mitragyna speciosa (Kratom) is a narcotic plant indigenous to Southeast
Asian countries, including Thailand. Traditionally, M. speciosa has been used as medicine …
Asian countries, including Thailand. Traditionally, M. speciosa has been used as medicine …
Receptor selectivity and therapeutic potential of kratom in substance use disorders
Abstract Purpose of Review Kratom (Mitragyna speciosa Korth) contains several alkaloids,
some interacting with opioid receptors and attracting recreational use in the western world …
some interacting with opioid receptors and attracting recreational use in the western world …
[HTML][HTML] RP-HPLC-DAD Analysis of Mitragynine Content in Mitragyna speciosa Korth. (Ketum) Leaf Extracts Prepared Using Ultrasound Assisted Extraction …
Mitragynine and its congeners are one of the major phytoconstituents present in Mitragyna
speciosa Korth.(ketum) leaves and a well-known factor that contributes to ketum's …
speciosa Korth.(ketum) leaves and a well-known factor that contributes to ketum's …