Purpose Although several MRI methods have been explored to achieve in vivo myelin
quantification, imaging the whole brain in clinically acceptable times and sufficiently high …

In spite of extensive work, inconsistent findings and lack of specificity in most neuroimaging
techniques used to examine age-and gender-related patterns in brain tissue microstructure …

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease characterized by
diffuse and focal areas of tissue loss. Conventional MRI techniques such as T1-weighted …

Long acquisition times preclude the application of multiecho spin echo (MESE) sequences
for myelin water fraction (MWF) mapping in daily clinical practice. In search of alternative …

Impaired myelin plays a central role in a wide range of degenerative brain diseases. A
method for non-invasive and in vivo assessment of myelin content within clinically …

This thesis focuses on the signal modelling of Diffusion-Weighted Magnetic Resonance
Imaging (DW-MRI) in the brain's white matter (WM). DW-MRI a non-invasive technique with …

In previous work, CAIPIRINHA was implemented in multi-echo gradient and spin echo
(GRASE) acquisitions for 3D myelin water imaging, achieving significant acceleration …