The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …

Pluripotent stem cells (PSCs) are characterized by their unique capacity for both unlimited
self-renewal and their potential to differentiate to all cell lineages contained within the three …

Cell fate determination requires faithful execution of gene expression programs, which are
increasingly recognized to respond to metabolic inputs. In particular, the family of α …

The pluripotency of mammalian early and late epiblast could be recapitulated by naïve
embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively …

Germline–soma segregation is a fundamental event during mammalian embryonic
development. Here we establish the epigenetic principles of human primordial germ cell …

Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic
signaling pathways and intracellular metabolites. Here we show that cell-permeable α …

While metabolism was initially thought to play a passive role in cell biology by generating
ATP to meet bioenergetic demands, recent studies have identified critical roles for …