Experimental efforts to understand how the brain represents, stores and processes
information require high-fidelity recordings of multiple different forms of neural activity within …

Over the past 20 years, protein engineering has been extensively used to improve and
modify the fundamental properties of fluorescent proteins (FPs) with the goal of adapting …

Genetically encoded voltage indicators are emerging tools for monitoring voltage dynamics
with cell-type specificity. However, current indicators enable a narrow range of applications …

The actions of neuromodulation are thought to mediate the ability of the mammalian brain to
dynamically adjust its functional state in response to changes in the environment. Altered …

Fluorescent tools have revolutionized our ability to probe biological dynamics, particularly at
the cellular level. Fluorescent sensors have been developed on several platforms, utilizing …

There have been two recent revolutionary advances in neuroscience: First, genetically
encoded activity sensors have brought the goal of optical detection of single action …

Imaging voltage using fluorescent-based sensors could be an ideal technique to probe
neural circuits with high spatiotemporal resolution. However, due to insufficient signal-to …

Highlights•Mechanosensitive ion channels are capable of transducing force into ion
flux.•Three families of plant MS channels are described to date and many more likely …

Genetically encoded fluorescent biosensors have revolutionized the study of cell signaling
and metabolism, as they allow for live-cell measurements with high spatiotemporal …

Rhodopsins had long been considered non-fluorescent until a peculiar voltage-sensitive
fluorescence was reported for archaerhodopsin-3 (Arch3) derivatives. These proteins …