An update on targeted treatment of IgA nephropathy: an autoimmune perspective
X Huang, G Xu - Frontiers in pharmacology, 2021 - frontiersin.org
Immunoglobulin (Ig) A nephropathy (IgAN) is the commonest form of primary
glomerulonephritis worldwide and is, considered a significant cause of end-stage renal …
glomerulonephritis worldwide and is, considered a significant cause of end-stage renal …
The contribution of complement to the pathogenesis of IgA nephropathy: are complement-targeted therapies moving from rare disorders to more common diseases?
F Poppelaars, B Faria, W Schwaeble… - Journal of clinical …, 2021 - mdpi.com
Primary IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and kidney
failure for which there is no disease-specific treatment. However, this could change, since …
failure for which there is no disease-specific treatment. However, this could change, since …
Immunological drivers of IgA nephropathy: Exploring the mucosa–kidney link
H Selvaskandan, J Barratt… - International Journal of …, 2022 - Wiley Online Library
IgA nephropathy (IgAN) is the most common pattern of primary glomerular disease reported
worldwide. Up to 40% of those with IgAN progress to end‐stage kidney disease within 20 …
worldwide. Up to 40% of those with IgAN progress to end‐stage kidney disease within 20 …
IgA nephropathy: an overview of drug treatments in clinical trials
H Selvaskandan, G Gonzalez-Martin… - Expert Opinion on …, 2022 - Taylor & Francis
ABSTRACT Introduction IgA nephropathy (IgAN) is the commonest primary
glomerulonephritis worldwide and may progress to end-stage kidney disease (ESKD) within …
glomerulonephritis worldwide and may progress to end-stage kidney disease (ESKD) within …
Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA1 Antibody in IgA Nephropathy Patients
YL Chiu, WC Lin, KH Shu, YW Fang… - Frontiers in …, 2021 - frontiersin.org
Background Galactose-deficient IgA1 (Gd-IgA1) and alternative complement pathway
activation are considered to be involved in the pathogenesis of IgA nephropathy (IgAN) …
activation are considered to be involved in the pathogenesis of IgA nephropathy (IgAN) …
Predictive prognostic value of glomerular C3 deposition in IgA nephropathy
M Xie, Y Zhu, X Wang, J Ren, H Guo, B Huang… - Journal of …, 2023 - Springer
Background IgAN is the most common primary glomerulonephritis worldwide. However, the
pathogenesis of IgAN remains unknown. Currently, there is evidence that C3 deposition …
pathogenesis of IgAN remains unknown. Currently, there is evidence that C3 deposition …
Severe glomerular C3 deposition indicates severe renal lesions and a poor prognosis in patients with immunoglobulin A nephropathy
J Wu, Z Hu, Y Wang, D Hu, Q Yang, Y Li, W Dai… - …, 2021 - Wiley Online Library
Aims Glomerular complement 3 (C3) deposition is often observed in renal biopsies of
patients with IgA nephropathy (IgAN); however, the relationship between the intensity of C3 …
patients with IgA nephropathy (IgAN); however, the relationship between the intensity of C3 …
[HTML][HTML] Glomerular C4d deposition and kidney disease progression in IgA nephropathy: a systematic review and meta-analysis
Y Jiang, J Zan, S Shi, W Hou, W Zhao, X Zhong, X Zhou… - Kidney Medicine, 2021 - Elsevier
Background Glomerular deposition of C4d is a widely used biomarker for activation of the
lectin pathway in the complement system and is reported to be associated with kidney …
lectin pathway in the complement system and is reported to be associated with kidney …
Mesangial C3 deposition and serum C3 levels predict renal outcome in IgA nephropathy
D Wu, X Li, X Yao, N Zhang, L Lei, H Zhang… - Clinical and …, 2021 - Springer
Background Complement activation plays an important role in the pathogenesis of IgA
nephropathy (IgAN). We aimed to evaluate the relationship between mesangial C3 …
nephropathy (IgAN). We aimed to evaluate the relationship between mesangial C3 …