Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

Inflammatory bowel disease (IBD) is a chronic immune-mediated disease affecting the
gastrointestinal tract. IBD consists of 2 subtypes: ulcerative colitis and Crohn disease. IBD is …

Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

Inflammatory bowel disease (IBD) is an intestinal inflammatory condition that affects more
than 2 million people in the United States. Although the etiology and pathogenesis of IBD …

Crohn's disease and ulcerative colitis are prototypical complex diseases characterized by
chronic and heterogeneous manifestations, induced by interacting environmental, genomic …

In recent years, investigators have readdressed the complex issues involved in the
classification of inflammatory bowel diseases. In 2003, a Working Party of investigators with …

Background Abnormal host–microbe interactions are implicated in the pathogenesis of
inflammatory bowel diseases. Previous 16S rRNA sequence analysis of intestinal tissues …

The traditional management of Crohn's disease, which is based on progressive, step-wise
treatment intensification with re-evaluation of response according to symptoms, does not …

The advent of biological therapy has revolutionized inflammatory bowel disease (IBD) care.
Nonetheless, not all patients require biological therapy. Selection of patients depends on …

▪ Abstract Nods are cytosolic proteins that contain a nucleotide-binding oligomerization
domain (NOD). These proteins include key regulators of apoptosis and pathogen resistance …