Abstract Purpose of Review Diabetic peripheral neuropathy eventually affects nearly 50% of
adults with diabetes during their lifetime and is associated with substantial morbidity …

Diabetic neuropathies are the most prevalent chronic complications of diabetes. This
heterogeneous group of conditions affects different parts of the nervous system and presents …

Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Opioid use in chronic pain treatment is complex, as patients may derive both benefit and
harm. Identification of individuals currently using opioids in a problematic way is important …

Background: Current treatments for chronic pain have limited effectiveness and commonly
known side effects. Given the prevalence and burden of intractable pain, additional …

Currently, ketamine is used in treating multiple pain, mental health, and substance abuse
disorders due to rapid-acting analgesic and antidepressant effects. Its limited short-term …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …

Background & aims Musculoskeletal pain, the most common cause of disability globally, is
most frequently managed in primary care. People with musculoskeletal pain in different body …

Chronic pain and mental health disorders are common in the general population, and
epidemiological studies suggest that a bidirectional relationship exists between these 2 …

Public health authorities have described, with growing alarm, an unprecedented increase in
morbidity and mortality associated with use of opioid pain relievers (OPRs). Efforts to …