Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …

Iron deficiency anaemia is a global health concern affecting children, women and the
elderly, whilst also being a common comorbidity in multiple medical conditions. The …

Abstract Iron deficiency anemia affects> 1.2 billions individuals worldwide, and iron
deficiency in the absence of anemia is even more frequent. Total-body (absolute) iron …

Hepcidin, the master regulator of systemic iron homeostasis, tightly influences erythrocyte
production. High hepcidin levels block intestinal iron absorption and macrophage iron …

Demanded as an essential trace element that supports cell growth and basic functions, iron
can be harmful and cancerogenic though. By exchanging between its different oxidized …

Decreased hepcidin mobilizes iron, which facilitates erythropoiesis, but excess iron is
pathogenic in β-thalassemia. Erythropoietin (EPO) enhances erythroferrone (ERFE) …

Hereditary iron overload includes several disorders characterized by iron accumulation in
tissues, organs, or even single cells or subcellular compartments. They are determined by …

Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes
in response to increased body iron concentration and inflammation. Deregulation of …

Iron is the most abundant metal in the human body. No independent life forms on earth can
survive without iron. However, excess iron is closely associated with carcinogenesis by …

Histone deacetylases (HDACs) are epigenetic regulators that play an important role in
determining cell fate and maintaining cellular homeostasis. However, whether and how …