[HTML][HTML] The role of inflammation in age-related macular degeneration
W Tan, J Zou, S Yoshida, B Jiang… - International journal of …, 2020 - ncbi.nlm.nih.gov
Age-related macular degeneration (AMD) is a blinding eye disease which incidence
gradually increases with age. Inflammation participates in AMD pathogenesis, including …
gradually increases with age. Inflammation participates in AMD pathogenesis, including …
A linkage between angiogenesis and inflammation in neovascular age-related macular degeneration
H Heloterä, K Kaarniranta - Cells, 2022 - mdpi.com
Age-related macular degeneration (AMD) is the leading cause of visual impairment in the
aging population with a limited understanding of its pathogenesis and the number of …
aging population with a limited understanding of its pathogenesis and the number of …
Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer
N Chaudhary, BS Choudhary, SG Shah… - … Journal of Cancer, 2021 - Wiley Online Library
Lipocalin 2 is a siderophore‐binding protein that regulates iron homeostasis. Lipocalin 2
expression is elevated in multiple tumor types; however, the mechanisms that drive tumor …
expression is elevated in multiple tumor types; however, the mechanisms that drive tumor …
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …
Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex-and age-related functional regulation
RJ Lu, S Taylor, K Contrepois, M Kim, JI Bravo… - Nature aging, 2021 - nature.com
Neutrophils are the most abundant human white blood cell and constitute a first line of
defense in the innate immune response. Neutrophils are short-lived cells and thus the …
defense in the innate immune response. Neutrophils are short-lived cells and thus the …
[HTML][HTML] Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases
DW Dekens, ULM Eisel, L Gouweleeuw… - Ageing research …, 2021 - Elsevier
Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …
The Role of Inflammation in Age-Related Macular Degeneration—Therapeutic Landscapes in Geographic Atrophy
Age-related macular degeneration (AMD) is the leading cause of vision loss and visual
impairment in people over 50 years of age. In the current therapeutic landscape, intravitreal …
impairment in people over 50 years of age. In the current therapeutic landscape, intravitreal …
Emerging role of neutrophil extracellular traps in the complications of diabetes mellitus
Immune dysfunction is widely regarded as one of the central tenants underpinning the
pathophysiology of diabetes mellitus (DM) and its complications. When discussing immunity …
pathophysiology of diabetes mellitus (DM) and its complications. When discussing immunity …
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes
Retinal ganglion cell axons are heavily myelinated (98%) and myelin damage in the optic
nerve (ON) severely affects vision. Understanding the molecular mechanism of …
nerve (ON) severely affects vision. Understanding the molecular mechanism of …
Microglia–neutrophil interactions drive dry AMD-like pathology in a mouse model
In dry age-related macular degeneration (AMD), inflammation plays a key role in disease
pathogenesis. Innate immune cells such as microglia and neutrophils infiltrate the sub …
pathogenesis. Innate immune cells such as microglia and neutrophils infiltrate the sub …