Simple Summary Beyond mutations, epigenetic changes have been described as drivers for
cancer as well. While leaving the overall DNA structure intact, they can be responsible for …

Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of
cells commonly termed “cancer stem cells” that has been proposed to be a strong driving …

A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

In the last years, mortality from breast cancer has declined in western countries as a
consequence of a more widespread screening resulting in earlier detection, as well as an …

Epigenetics is the study of heritable alterations in gene expression that are not accompanied
by the corresponding change in DNA sequence. Three interlinked epigenetic processes …

Epigenetic treatment has been approved by regulatory agencies for haematological
malignancies. The success observed in cutaneous lymphomas represents a proof of …

Simple Summary Breast cancer (BC) is the most frequent malignancy diagnosed in 2020
worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully …

Breast cancer exhibits various epigenetic abnormalities that regulate gene expression and
contribute to tumor characteristics. Epigenetic alterations play a significant role in cancer …

Motivation Drug repositioning is an effective strategy to identify new indications for existing
drugs, providing the quickest possible transition from bench to bedside. With the rapid …

Highlights•Breast cancer is the most frequently diagnosed cancer in women.•Aberrant
expression of HATs and HDACs has been reported in breast cancer.•Epigenetic therapy is …