Abstract PI3K/AKT signaling pathway plays an important role in tumorigenesis and regulates
critical cellular functions including survival, proliferation and metabolism. PIK3CA mutations …

Triple-negative breast cancer (TNBC) accounts for 15–20% of all breast cancers and is
characterized by an aggressive nature and a high rate of recurrence despite neoadjuvant …

Highlights•Breast cancer in young women should be treated based on stage and biology of
disease.•Management of breast cancer in young women requires special considerations …

Abstract The 3rd International Consensus Conference for Breast Cancer in Young Women
(BCY3) took place in November 2016, in Lugano, Switzerland organized by the European …

Purpose We investigated disease-free survival (DFS) and overall survival (OS) after
response-guided neoadjuvant chemotherapy in patients with early breast cancer. Patients …

PURPOSE The West German Study Group PlanB trial evaluated an anthracycline-free
chemotherapy standard (six cycles of docetaxel and cyclophosphamide [TC]) in the routine …

The taxane chemotherapeutic agent docetaxel has been utilized in the management of
breast cancer in the adjuvant, neoadjuvant and metastatic setting. Although well tolerated by …

Ziele Das Ziel dieser offiziellen Leitlinie, die von der Deutschen Gesellschaft für
Gynäkologie und Geburtshilfe (DGGG) und der Deutschen Krebsgesellschaft (DKG) …

Locally advanced breast cancer (LABC) constitutes a heterogeneous entity that includes
advanced-stage primary tumours, cancers with extensive nodal involvement and …

Purpose Approximately 35% of HER2-amplified breast cancers have coamplification of the
topoisomerase II-alpha (TOP2A) gene encoding an enzyme that is a major target of …