Microbiome and human health: current understanding, engineering, and enabling technologies

N Aggarwal, S Kitano, GRY Puah, S Kittelmann… - Chemical …, 2022 - ACS Publications
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

How vascular smooth muscle cell phenotype switching contributes to vascular disease

G Cao, X Xuan, J Hu, R Zhang, H Jin… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair

L He, W Pu, X Liu, Z Zhang, M Han, YI Li, X Huang… - Science, 2021 - science.org
INTRODUCTION Cell proliferation is a fundamental process in all multicellular organisms
that is required to enable development, tissue homeostasis, tissue repair, and tissue …

[HTML][HTML] Tracing the skeletal progenitor transition during postnatal bone formation

HS Shu, YL Liu, XT Tang, XS Zhang, B Zhou, W Zou… - Cell Stem Cell, 2021 - cell.com
Multiple distinct types of skeletal progenitors have been shown to contribute to
endochondral bone development and maintenance. However, the division of labor and …

Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer's disease in mice

Y Wu, JH Dong, YF Dai, MZ Zhu, MY Wang, Y Zhang… - Neuron, 2023 - cell.com
Alzheimer's disease (AD) is caused by a complex interaction between genetic and
environmental factors. However, how the role of peripheral organ changes in response to …

[HTML][HTML] Stem cells and the differentiation hierarchy in mammary gland development

NY Fu, E Nolan, GJ Lindeman… - Physiological …, 2020 - journals.physiology.org
The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Smooth muscle cell phenotypic diversity: At the crossroads of lineage tracing and single-cell transcriptomics

M Liu, D Gomez - Arteriosclerosis, thrombosis, and vascular …, 2019 - Am Heart Assoc
Vascular smooth muscle cells (SMC) play a critical role in controlling blood pressure and
blood distribution, as well as maintaining the structural integrity of the blood vessel. SMC …

Dual genetic tracing reveals a unique fibroblast subpopulation modulating cardiac fibrosis

M Han, Z Liu, L Liu, X Huang, H Wang, W Pu, E Wang… - Nature Genetics, 2023 - nature.com
After severe heart injury, fibroblasts are activated and proliferate excessively to form
scarring, leading to decreased cardiac function and eventually heart failure. It is unknown …

Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase

MR Reboll, S Klede, MH Taft, CL Cai, LJ Field… - Science, 2022 - science.org
Effective tissue repair after myocardial infarction entails a vigorous angiogenic response,
guided by incompletely defined immune cell–endothelial cell interactions. We identify the …

Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction

Q Liu, K Liu, G Cui, X Huang, S Yao, W Guo, Z Qin… - Nature …, 2019 - nature.com
Characterizing the stem cells responsible for lung repair and regeneration is important for
the treatment of pulmonary diseases. Recently, a unique cell population located at the …