Stroke is the second leading cause of death and a major contributor to disability worldwide.
The prevalence of stroke is highest in developing countries, with ischemic stroke being the …

Background The pharmaceutical industry is in the midst of a productivity crisis and rates of
translation from bench to bedside are dismal. Patients are being let down by the current …

Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …

This review outlines the most frequently used rodent stroke models and discusses their
strengths and shortcomings. Mimicking all aspects of human stroke in one animal model is …

Astrocytes are the most abundant cell type within the central nervous system. They play
essential roles in maintaining normal brain function, as they are a critical structural and …

Cerebral microinfarcts are small lesions that are presumed to be ischaemic. Despite the
small size of these lesions, affected individuals can have hundreds to thousands of cerebral …

Rabies is one of the most deadly infectious diseases, with a case-fatality rate approaching
100%. The disease is established on all continents apart from Antarctica; most cases are …

Acute ischaemic stroke accounts for 6.5 million deaths per year, and by 2030 will result in
the annual loss of over 200 million disability-adjusted life years globally. There have been …

Stroke is the third cause of death worldwide and the main cause of chronic, severe adult
disability. We focus on acute ischaemic stroke, which accounts for approximately 80% of all …

Stroke is one of the leading causes of death worldwide. A strong inflammatory response
characterized by activation and release of cytokines, chemokines, adhesion molecules, and …