Conspectus The halogen–metal exchange reaction is a very powerful method for preparing
functionalized organometallic reagents in the fields of organic and organometallic chemistry …

We report a practical in situ quench (ISQ) procedure involving the generation of chiral
secondary alkyllithiums from secondary alkyl iodides (including functionalized iodides …

Chiral secondary alkylcopper reagents were prepared from chiral secondary alkyl iodides by
a retentive I/Li exchange followed by a retentive transmetalation with CuBr⋅ P (OEt) 3 …

Optically enriched secondary alkyl iodides were converted into secondary alkyllithium and
secondary alkylcopper compounds with very high retention of configuration. Quenching with …

Stereotriads bearing allylic alcohols are privileged structures in natural products, and new
methods accessing these in a stereoselective fashion are highly sought after. Toward this …

A mild and practical Barbier–Negishi coupling of secondary alkyl bromides with aryl and
alkenyl triflates and nonaflates has been developed. This challenging reaction was enabled …

A copper (I)-mediated cross-coupling of stereodefined secondary alkyllithiums with
bromoalkynes provided stereodefined alkynes with high diastereoselectivity (dr up to 98: 2) …

The synthesis of alkyl esters from readily available alkyl halides and chloroformates was
achieved for the first time using a mild Ni-catalyzed reductive coupling protocol. Unactivated …

The preparation of chiral non-stabilized open-chain alkyllithium reagents prepared from the
corresponding chiral secondary alkyl iodides and their subsequent transmetalation to the …

Functionalized secondary alkyllithium reagents obtained by I/Li exchange from the
corresponding secondary alkyl iodides undergo two successive transmetalations with …