Microfluidics for neuronal cell and circuit engineering

R Habibey, JE Rojo Arias, J Striebel… - Chemical …, 2022 - ACS Publications
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke

B Campos, H Choi, AT DeMarco… - Journal of …, 2023 - Soc Neuroscience
Stroke is one of the most common causes of disability, and there are few treatments that can
improve recovery after stroke. Therapeutic development has been hindered because of a …

Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays

R Habibey, J Striebel, F Schmieder, J Czarske… - Frontiers in …, 2022 - frontiersin.org
Comprehensive electrophysiological characterizations of human induced pluripotent stem
cell (hiPSC)-derived neuronal networks are essential to determine to what extent these in …

Longitudinal functional imaging of VIP interneurons reveals sup-population specific effects of stroke that are rescued with chemogenetic therapy

M Motaharinia, K Gerrow, R Boghozian, E White… - Nature …, 2021 - nature.com
Stroke profoundly disrupts cortical excitability which impedes recovery, but how it affects the
function of specific inhibitory interneurons, or subpopulations therein, is poorly understood …

PDE2A inhibition enhances axonal sprouting, functional connectivity, and recovery after stroke

KR Bechay, N Abduljawad, S Latifi… - Journal of …, 2022 - Soc Neuroscience
Phosphodiesterase (PDE) inhibitors have been safely and effectively used in the clinic and
increase the concentration of intracellular cyclic nucleotides (cAMP/cGMP). These …

Molecular mechanisms of Neuroprotection after the intermittent exposures of Hypercapnic Hypoxia

PP Tregub, VP Kulikov, I Ibrahimli, OF Tregub… - International Journal of …, 2024 - mdpi.com
The review introduces the stages of formation and experimental confirmation of the
hypothesis regarding the mutual potentiation of neuroprotective effects of hypoxia and …

Two-photon microscopy: application advantages and latest progress for in vivo imaging of neurons and blood vessels after ischemic stroke

J Li, X Wu, Y Fu, H Nie, Z Tang - Reviews in the Neurosciences, 2023 - degruyter.com
Two-photon microscopy (TPM) plays an important role in the study of the changes of the two
important components of neurovascular units (NVU)–neurons and blood vessels after …

Biology-driven material design for ischaemic stroke repair

NV Phan, EM Rathbun, Y Ouyang… - Nature Reviews …, 2024 - nature.com
Ischaemic stroke remains a leading cause of disability, with current clinical treatment options
mainly focusing on mitigating immediate damage. The limited self-renewing capacity of the …

Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke

L Guo, S Kondapavulur, SM Lemke, SJ Won… - Cell reports, 2021 - cell.com
Skilled movements rely on a coordinated cortical and subcortical network, but how this
network supports motor recovery after stroke is unknown. Previous studies focused on the …

Incubator-independent perfusion system integrated with microfluidic device for continuous electrophysiology and microscopy readouts

R Habibey - Biofabrication, 2023 - iopscience.iop.org
Advances in primary and stem cell derived neuronal cell culture techniques and abundance
of available neuronal cell types have enabled in vitro neuroscience as a substantial …