Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

Biological membranes formed of amphipathic lipid bilayers provide chemical barriers to
separate cells from their external environments and define subcellular compartments …

Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …

Detergents enable the investigation of membrane proteins by mass spectrometry. Detergent
designers aim to improve underlying methodologies and are confronted with the challenge …

Stabilities and structure (s) of proteins are directly coupled to their local environment or
Gibbs free energy landscape as defined by solvent, temperature, pressure, and …

Mass spectrometry (MS) plays a key role throughout all stages of drug development and is
now as ubiquitous as other analytical techniques such as surface plasmon resonance …

While it is known that lipids play an essential role in regulating membrane protein structure
and function, it remains challenging to identify specific protein–lipid interactions. Here, we …

Further increase in the acidity in the most denaturing acidic solution is known to induce
compaction of the fully unfolded protein into a compact molten globule. The phenomenon of …

TRAAK is an ion channel from the two-pore domain potassium (K2P) channel family with
roles in maintaining the resting membrane potential and fast action potential conduction …

Collision cross‐section values, which can be determined using ion mobility experiments, are
sensitive to the structures of protein ions and useful for applications to structural biology and …