Living organisms are capable of inducing the crystallization and deposition of a wide variety
of minerals, 1 but the vertebrates mainly utilize the calcium phosphates in constructing their …

Metastases arising from tumors have the proclivity to colonize specific organs, suggesting
that they must rewire their biology to meet the demands of the organ colonized, thus altering …

Abstract Background Cancer‐associated fibroblasts (CAFs) play an important role in the
induction of chemo‐resistance. This study aimed to clarify the mechanism underlying CAF …

NMR spectroscopy is the only method to access the structural dynamics of biomolecules at
high (atomistic) resolution in their native solution state. However, this method's low …

Interactions between tumor cells and cancer-associated fibroblasts (CAFs) in the tumor
microenvironment significantly influence cancer growth and metastasis. Transforming …

Numerous components and pathways are involved in the complex interplay between cancer
cells and their environment. The family of glycophosphoproteins comprising osteopontin …

Langerhans cell histiocytosis (LCH) is a rare disease characterized by heterogeneous
lesions containing CD207+ Langerhans cells (LCs) and lymphocytes that can arise in …

Substantial advances have been made recently in the pathobiology of pituitary tumors.
Similar to many other endocrine tumors, over the last few years we have recognized the role …

Background The ductal carcinoma in situ (DCIS) of the mammary gland represents an early,
pre-invasive stage in the development of invasive breast carcinoma. Since DCIS is a curable …

Clinical and experimental evidence indicates that tumor-associated macrophages (TAMs)
promote malignant progression. In breast cancer, TAMs enhance tumor angiogenesis, tumor …