Discovery of molecular glue degraders via isogenic morphological profiling
A Ng, F Offensperger, JA Cisneros… - ACS Chemical …, 2023 - ACS Publications
Molecular glue degraders (MGDs) are small molecules that degrade proteins of interest via
the ubiquitin–proteasome system. While MGDs were historically discovered serendipitously …
the ubiquitin–proteasome system. While MGDs were historically discovered serendipitously …
[HTML][HTML] Deciphering actin remodelling in immune cells through the prism of actin-related inborn errors of immunity
L Dupré, G Prunier - European Journal of Cell Biology, 2023 - Elsevier
Actin cytoskeleton remodelling drives cell motility, cell to cell contacts, as well as membrane
and organelle dynamics. Those cellular activities operate at a particularly high pace in …
and organelle dynamics. Those cellular activities operate at a particularly high pace in …
Reproducible image-based profiling with Pycytominer
E Serrano, SN Chandrasekaran, D Bunten, KI Brewer… - ArXiv, 2024 - pmc.ncbi.nlm.nih.gov
Advances in high-throughput microscopy have enabled the rapid acquisition of large
numbers of high-content microscopy images. Whether by deep learning or classical …
numbers of high-content microscopy images. Whether by deep learning or classical …
[HTML][HTML] A next-generation dynamic programming language Julia: Its features and applications in biological science
Abstract Background The advent of Julia as a sophisticated and dynamic programming
language in 2012 represented a significant milestone in computational programming …
language in 2012 represented a significant milestone in computational programming …
[HTML][HTML] Evolution and impact of high content imaging
Abstract/outline The field of high content imaging has steadily evolved and expanded
substantially across many industry and academic research institutions since it was first …
substantially across many industry and academic research institutions since it was first …
Metrics of 2D immunological synapses in human T cells via high-content confocal cell imaging
G Prunier, B Chaves, C Lacouture, L Dupré - Methods in Cell Biology, 2023 - Elsevier
Immunological synapses (IS) are the privileged site of complex information transfer between
T cells and antigen presenting cells. IS are highly structured in terms of actin and tubulin …
T cells and antigen presenting cells. IS are highly structured in terms of actin and tubulin …