Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …

Epstein-Barr virus (EBV) provides a useful model to study cellular immunity to a genetically
stable, persistent human virus. Different sets of proteins expressed during EBV's lytic and …

Alzheimer's disease is an incurable neurodegenerative disorder in which neuroinflammation
has a critical function. However, little is known about the contribution of the adaptive immune …

Generation and maintenance of an effective repertoire of T cell antigen receptors are
essential to the immune system, yet the number of distinct T cell receptors (TCRs) expressed …

Diversity in T lymphocyte antigen receptors is generated by somatic rearrangement of T cell
receptor (TCR) genes and is concentrated within the third complementarity-determining …

The deterioration in immune function with aging is thought to make a major contribution to
the increased morbidity and mortality from infectious disease in old age. One aspect of …

▪ Abstract Epstein-Barr virus (EBV) provides one of the most informative systems with which
to study cytotoxic T lymphocyte (CTL) responses in humans. The virus establishes a highly …

Public T-cell responses, in which T cells bearing identical T-cell receptors (TCRs) are
observed to dominate the response to the same antigenic epitope in multiple individuals …

Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or
hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors …

Graft-versus-host disease and graft rejection are major complications of allogeneic HLA-
mismatched stem cell transplantation or organ transplantation that are caused by …