Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …

Angiogenesis is the process through which new blood vessels are formed from preexisting
ones and plays a critical role in several conditions including embryonic development, tissue …

Activation of myofibroblast rich stroma is a rate-limiting step essential for cancer progression.
The responsible factors are not fully understood, but TGFβ1 is probably critical. A proportion …

Stromal fibroblasts become altered in response to solid cancers, to exhibit myofibroblastic
characteristics, with disease promoting influence. Infiltrating mesenchymal stem cells (MSC) …

The characteristic desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a
key contributor to its lethality. This stromal microenvironment is populated by cancer …

The fields of regenerative medicine and tissue engineering offer significant promise to
address the urgent unmet need for therapeutic strategies in a number of debilitating …

Cell spheroids represent attractive building units for bone tissue engineering, because they
provide a threedimensional environment with intensive direct cellcell contacts. Moreover …

Site-specific chemical dimerization of fibroblast growth factor 2 (FGF2) with the optimal linker
length resulted in a FGF2 homodimer with improved granulation tissue formation and blood …

microRNAs or miRs have been shown to be pivotal modulators of vascular development.
The strand and cell type-specific function of miR-126 in angiogenesis, especially …

Vascular-disrupting agents are an interesting class of anticancer compounds because of
their combined mode of action in preventing new blood vessel formation and disruption of …