Candida albicans Biofilms and Human Disease
CJ Nobile, AD Johnson - Annual review of microbiology, 2015 - annualreviews.org
In humans, microbial cells (including bacteria, archaea, and fungi) greatly outnumber host
cells. Candida albicans is the most prevalent fungal species of the human microbiota; this …
cells. Candida albicans is the most prevalent fungal species of the human microbiota; this …
[PDF][PDF] Global genetic networks and the genotype-to-phenotype relationship
Genetic interactions identify combinations of genetic variants that impinge on phenotype.
With whole-genome sequence information available for thousands of individuals within a …
With whole-genome sequence information available for thousands of individuals within a …
The BioGRID interaction database: 2013 update
A Chatr-Aryamontri, BJ Breitkreutz… - Nucleic acids …, 2012 - academic.oup.com
Abstract The Biological General Repository for Interaction Datasets (BioGRID:
http//thebiogrid. org) is an open access archive of genetic and protein interactions that are …
http//thebiogrid. org) is an open access archive of genetic and protein interactions that are …
The yeast deletion collection: a decade of functional genomics
The yeast deletion collections comprise> 21,000 mutant strains that carry precise start-to-
stop deletions of∼ 6000 open reading frames. This collection includes heterozygous and …
stop deletions of∼ 6000 open reading frames. This collection includes heterozygous and …
Candida albicans triggers NLRP3-mediated pyroptosis in macrophages
M Wellington, K Koselny, FS Sutterwala… - Eukaryotic cell, 2014 - Am Soc Microbiol
Pyroptosis is an inflammasome-mediated programmed cell death pathway triggered in
macrophages by a variety of stimuli, including intracellular bacterial pathogens. Activation of …
macrophages by a variety of stimuli, including intracellular bacterial pathogens. Activation of …
Global analysis of fungal morphology exposes mechanisms of host cell escape
TR O'Meara, AO Veri, T Ketela, B Jiang… - Nature …, 2015 - nature.com
Developmental transitions between single-cell yeast and multicellular filaments underpin
virulence of diverse fungal pathogens. For the leading human fungal pathogen Candida …
virulence of diverse fungal pathogens. For the leading human fungal pathogen Candida …
A CRISPR–Cas9-based gene drive platform for genetic interaction analysis in Candida albicans
Candida albicans is the leading cause of fungal infections; yet, complex genetic interaction
analysis remains cumbersome in this diploid pathogen. Here, we developed a CRISPR …
analysis remains cumbersome in this diploid pathogen. Here, we developed a CRISPR …
Systematic Phenotyping of a Large-Scale Candida glabrata Deletion Collection Reveals Novel Antifungal Tolerance Genes
T Schwarzmueller, B Ma, E Hiller, F Istel… - PLoS …, 2014 - journals.plos.org
The opportunistic fungal pathogen Candida glabrata is a frequent cause of candidiasis,
causing infections ranging from superficial to life-threatening disseminated disease. The …
causing infections ranging from superficial to life-threatening disseminated disease. The …
Exploring whole-genome duplicate gene retention with complex genetic interaction analysis
INTRODUCTION Whole-genome duplication (WGD) events are pervasive in eukaryotes,
shaping the genomes of simple single-celled organisms, such as yeast, as well as those of …
shaping the genomes of simple single-celled organisms, such as yeast, as well as those of …
Gene Essentiality Analyzed by In Vivo Transposon Mutagenesis and Machine Learning in a Stable Haploid Isolate of Candida albicans
Knowing the full set of essential genes for a given organism provides important information
about ways to promote, and to limit, its growth and survival. For many non-model organisms …
about ways to promote, and to limit, its growth and survival. For many non-model organisms …