Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …

The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Highlights•Non-acetyl histone acylations are catalyzed by classical acetylation
modifiers.•Active site engagement of the acyl group determines acyl type-specific …

BRD4-NUT, a driver fusion mutant in rare and highly aggressive NUT carcinoma, acts in
aberrant transcription of anti-differentiation genes by recruiting histone acetyltransferase …

Simple Summary Through their regulatory effects on gene expression, histone
acetyltransferases have been implicated in the normal physiological activities and genesis …

It remains poorly understood about the regulation of gene and transposon transcription
during human early embryogenesis. Here, we report that broad H3K27ac domains are …

Histone acetylation is important for the activation of gene transcription but little is known
about its direct read/write mechanisms. Here, we report cryogenic electron microscopy …

Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix
proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified …

Transcription coactivators are proteins or protein complexes that mediate transcription factor
(TF) function. However, they lack DNA-binding capacity, prompting the question of how they …