CFTR modulators: the changing face of cystic fibrosis in the era of precision medicine
M Lopes-Pacheco - Frontiers in pharmacology, 2020 - frontiersin.org
Cystic fibrosis (CF) is a lethal inherited disease caused by mutations in the CF
transmembrane conductance regulator (CFTR) gene, which result in impairment of CFTR …
transmembrane conductance regulator (CFTR) gene, which result in impairment of CFTR …
Structure, gating, and regulation of the CFTR anion channel
The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …
The ABC protein turned chloride channel whose failure causes cystic fibrosis
CFTR chloride channels are encoded by the gene mutated in patients with cystic fibrosis.
These channels belong to the superfamily of ABC transporter ATPases. ATP-driven …
These channels belong to the superfamily of ABC transporter ATPases. ATP-driven …
CFTR modulators: shedding light on precision medicine for cystic fibrosis
M Lopes-Pacheco - Frontiers in pharmacology, 2016 - frontiersin.org
Cystic fibrosis (CF) is the most common life-threatening monogenic disease afflicting
Caucasian people. It affects the respiratory, gastrointestinal, glandular and reproductive …
Caucasian people. It affects the respiratory, gastrointestinal, glandular and reproductive …
Structural mechanisms of CFTR function and dysfunction
Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) chloride channel plays a
critical role in regulating transepithelial movement of water and electrolyte in exocrine …
critical role in regulating transepithelial movement of water and electrolyte in exocrine …
PKC regulation of ion channels: The involvement of PIP2
KD Gada, DE Logothetis - Journal of Biological Chemistry, 2022 - ASBMB
Ion channels are integral membrane proteins whose gating has been increasingly shown to
depend on the presence of the low-abundance membrane phospholipid …
depend on the presence of the low-abundance membrane phospholipid …
Pharmacological modulation of ion channels for the treatment of cystic fibrosis
MC Pinto, IAL Silva, MF Figueira… - Journal of …, 2021 - Taylor & Francis
Cystic fibrosis (CF) is a life-shortening monogenic disease caused by mutations in the gene
encoding the CF transmembrane conductance regulator (CFTR) protein, an anion channel …
encoding the CF transmembrane conductance regulator (CFTR) protein, an anion channel …
CFTR structure and cystic fibrosis
N Cant, N Pollock, RC Ford - The international journal of biochemistry & …, 2014 - Elsevier
CFTR (cystic fibrosis transmembrane conductance regulator) is a member of the ATP-
binding cassette family of membrane proteins. Although almost all members of this family …
binding cassette family of membrane proteins. Although almost all members of this family …
Pathogenic relationships in cystic fibrosis and renal diseases: CFTR, SLC26A9 and anoctamins
K Kunzelmann, J Ousingsawat, A Kraus… - International journal of …, 2023 - mdpi.com
The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to
have more in common than initially suspected, as they all participate in the pathogenic …
have more in common than initially suspected, as they all participate in the pathogenic …
Anoctamins
K Kunzelmann, Y Tian, JR Martins, D Faria… - … -European Journal of …, 2011 - Springer
Abstract Endogenous Ca 2+-activated Cl− channels (CaCC) demonstrate biophysical and
pharmacological properties that are well represented in cells overexpressing anoctamin 1 …
pharmacological properties that are well represented in cells overexpressing anoctamin 1 …