An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration
G Burnstock - Neuropharmacology, 2016 - Elsevier
Purinergic signalling appears to play important roles in neurodegeneration, neuroprotection
and neuroregeneration. Initially there is a brief summary of the background of purinergic …
and neuroregeneration. Initially there is a brief summary of the background of purinergic …
[HTML][HTML] Remyelination in multiple sclerosis: findings in the cuprizone model
H Leo, M Kipp - International Journal of Molecular Sciences, 2022 - mdpi.com
Remyelination therapies, which are currently under development, have a great potential to
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …
[HTML][HTML] White matter damage after traumatic brain injury: a role for damage associated molecular patterns
Traumatic brain injury (TBI) is a leading cause of mortality and long-term morbidity
worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on …
worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on …
Mechanistic insight on the role of leukotriene receptors in ischemic–reperfusion injury
Leukotrienes (LT) are a class of inflammatory mediators produced by the 5-lipoxygenase (5-
LO) enzyme from arachidonic acid (AA). We discussed the various LT inhibitors and …
LO) enzyme from arachidonic acid (AA). We discussed the various LT inhibitors and …
Synthesis and preclinical validation of novel indole derivatives as a GPR17 agonist for glioblastoma treatment
P Nguyen, P Doan, T Rimpilainen… - Journal of medicinal …, 2021 - ACS Publications
The discovery of a potential ligand-targeting G protein-coupled receptor 17 (GPR17) is
important for developing chemotherapeutic agents against glioblastoma multiforme (GBM) …
important for developing chemotherapeutic agents against glioblastoma multiforme (GBM) …
[HTML][HTML] The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke
E Bonfanti, P Gelosa, M Fumagalli, L Dimou… - Cell death & …, 2017 - nature.com
Following stroke-induced neuronal damage, quiescent oligodendrocyte precursors (OPCs)
are activated to proliferate and later to differentiate to myelin-producing cells. GPR17, a …
are activated to proliferate and later to differentiate to myelin-producing cells. GPR17, a …
Olig2-targeted G-protein-coupled receptor Gpr17 regulates oligodendrocyte survival in response to lysolecithin-induced demyelination
Z Ou, Y Sun, L Lin, N You, X Liu, H Li, Y Ma… - Journal of …, 2016 - Soc Neuroscience
Demyelinating diseases, such as multiple sclerosis, are known to result from acute or
chronic injury to the myelin sheath and inadequate remyelination; however, the underlying …
chronic injury to the myelin sheath and inadequate remyelination; however, the underlying …
Regulation and signaling of the GPR17 receptor in oligodendroglial cells
D Lecca, S Raffaele, MP Abbracchio, M Fumagalli - Glia, 2020 - Wiley Online Library
Remyelination, namely, the formation of new myelin sheaths around denuded axons,
counteracts axonal degeneration and restores neuronal function. Considerable advances …
counteracts axonal degeneration and restores neuronal function. Considerable advances …
[HTML][HTML] Leukotrienes vs. Montelukast—activity, metabolism, and toxicity hints for repurposing
Increasing environmental distress is associated with a growing asthma incidence; no
treatments are available but montelukast (MTK)—an antagonist of the cysteinyl leukotrienes …
treatments are available but montelukast (MTK)—an antagonist of the cysteinyl leukotrienes …