Purinergic signalling appears to play important roles in neurodegeneration, neuroprotection
and neuroregeneration. Initially there is a brief summary of the background of purinergic …

Remyelination therapies, which are currently under development, have a great potential to
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …

White matter (WM) tracts are bundles of myelinated axons that provide for rapid
communication throughout the CNS and integration in grey matter (GM). The main cells in …

Traumatic brain injury (TBI) is a leading cause of mortality and long-term morbidity
worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on …

Leukotrienes (LT) are a class of inflammatory mediators produced by the 5-lipoxygenase (5-
LO) enzyme from arachidonic acid (AA). We discussed the various LT inhibitors and …

The discovery of a potential ligand-targeting G protein-coupled receptor 17 (GPR17) is
important for developing chemotherapeutic agents against glioblastoma multiforme (GBM) …

Following stroke-induced neuronal damage, quiescent oligodendrocyte precursors (OPCs)
are activated to proliferate and later to differentiate to myelin-producing cells. GPR17, a …

Demyelinating diseases, such as multiple sclerosis, are known to result from acute or
chronic injury to the myelin sheath and inadequate remyelination; however, the underlying …

Remyelination, namely, the formation of new myelin sheaths around denuded axons,
counteracts axonal degeneration and restores neuronal function. Considerable advances …

Increasing environmental distress is associated with a growing asthma incidence; no
treatments are available but montelukast (MTK)—an antagonist of the cysteinyl leukotrienes …