A growing number of studies have evidenced non-telomeric functions of “telomerase”.
Almost all of them, however, investigated the non-canonical effects of the catalytic subunit …

In rapid proliferating cancer cells, there is a need for fast ATP and lactate production,
therefore cancer cells turn off oxidative phosphorylation and turn on the so called" Warburg …

Cadmium (Cd) is a common contaminant in environment. Crayfish are considered suitable
for indicating the impact of heavy metals on the environment. However, there is limited …

Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …

Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …

Rare minnow (Gobiocypris rarus) is a widely used experimental fish in risk assessments of
aquatic pollutants in China. Cadmium (Cd) is one of the most toxic heavy metals in the …

Mevalonate kinase (MVK) is an essential enzyme acting in early steps of sterol isoprenoids
biosynthesis, such as cholesterol in humans or ergosterol in trypanosomatids. MVK is …

One of the most important mechanisms for repairing double-strand breaks (DSBs) in model
eukaryotes is homologous recombination (HR). Although the genes involved in HR have …

This paper presents a parallel simulated annealing algorithm that is able to achieve 90%
parallel efficiency in iteration on up to 192 processors and up to 40% parallel efficiency in …

Chromatin associated proteins are key regulators of many important processes in the cell.
Trypanosoma cruzi, a protozoa flagellate that causes Chagas disease, alternates between …