In clinical trials, biochemical markers provide useful information on the drug's mode of
action, therapeutic response and side effect monitoring and can act as surrogate endpoints …

Declines in physical performance and cognition are commonly observed in older adults. The
geroscience paradigm posits that a set of processes and pathways shared among age …

Ageing is accompanied by an inexorable loss of muscle mass and functionality and
represents a major risk factor for numerous diseases such as cancer, diabetes and …

Human biological aging from maturity to senescence is associated with a gradual loss of
muscle mass and neuromuscular function. It is not until very old age (> 80 years) however …

Background Ageing is accompanied by a progressive loss of skeletal muscle mass and
strength, potentially determining the insurgence of sarcopenia. Evidence suggests that …

Patients with chronic obstructive pulmonary disease (COPD) present with an advanced form
of age-related muscle loss or sarcopenia. Among multiple pathomechanisms of sarcopenia …

Sarcopenia, or age-related decline in muscle form and function, exerts high personal,
societal, and economic burdens when untreated. Integrity and function of the neuromuscular …

Background Efforts to enhance diagnostic measures for sarcopenia have led to an
increased focus on the screening utility of blood‐based biomarkers. In this regard …

Aging is associated with gradual degeneration, in mass and function, of the neuromuscular
system. This process, referred to as “sarcopenia”, is considered a disease by itself, and it …

This study investigated the effects of an eight-week dual-task training with and without blood
flow restriction (BFR) on muscle quality (MQ) biomarkers, physical and cognitive functions in …