Cachexia is a devastating, multifactorial and often irreversible systemic syndrome
characterized by substantial weight loss (mainly of skeletal muscle and adipose tissue) that …

Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …

Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …

Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …

Diverse inflammatory diseases, infections and malignancies are associated with wasting
syndromes. In many of these conditions, the standards for diagnosis and treatment are …

Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Cancer cachexia is a systemic hypoanabolic and catabolic syndrome that diminishes the
quality of life of cancer patients, decreases the efficiency of therapeutic strategies and …

Cancer cachexia (CC) is a multifactorial syndrome in patients with advanced cancer
characterized by weight loss via skeletal-muscle and adipose-tissue atrophy, catabolic …

Our study was to characterize sarcopenia in C57BL/6J mice using a clinically relevant
definition to investigate the underlying molecular mechanisms. Aged male (23–32 months …

Mitochondria are an important energy source in skeletal muscle. A main function of
mitochondria is the generation of ATP for energy through oxidative phosphorylation …