Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

Oxidative stress is considered to be involved in the pathophysiology of all cancers. In order
to evaluate the total oxidant/antioxidant status in patients with thyroid cancer and to …

Exposure to ionizing radiation during childhood markedly increases the risk of developing
papillary thyroid cancer. We examined tissues from 26 Ukrainian patients with thyroid cancer …

Thyroid pathology encompasses a heterogenous group of clinicopathological entities
including rare and diagnostically challenging neoplasms. The review is focused on …

BACKGROUND & AIMS: Mosaic G-protein alpha-subunit (GNAS)-activating mutations are
responsible for the McCune–Albright (MCA) syndrome. This oncogene that activates the …

Somatically acquired, activating mutations of GNAS, the gene encoding the stimulatory G-
protein Gsα subunit, have been identified in kidney, thyroid, pituitary, leydig cell …

Simple Summary Colorectal cancer progression involves multi-gene aberration of several
biomarkers via the downstream regulation of the MARK/ERK cascade. GNAS gene mutation …

Protein Kinase A is an evolutionarily-conserved protein which has been studied in model
organisms from yeast to man. Although the cAMP-PKA signaling system was the first …

Three syndromes affecting the thyroid gland are described in the literature separately:
familial nonautoimmune hyperthyroidism, sporadic congenital nonautoimmune …

Constitutive activation of STAT (Signal Transducer and Activator of Transcription)
transcription factors is a common feature identified in numerous tumors. Inflammatory …