The aryl hydrocarbon receptor: multitasking in the immune system
B Stockinger, PD Meglio, M Gialitakis… - Annual review of …, 2014 - annualreviews.org
The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the
pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2, 3 …
pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2, 3 …
Aryl hydrocarbon receptor promotes IL-10 expression in inflammatory macrophages through Src-STAT3 signaling pathway
J Zhu, L Luo, L Tian, S Yin, X Ma, S Cheng… - Frontiers in …, 2018 - frontiersin.org
The aryl hydrocarbon receptor (AhR) is an important immune regulator with a role in
inflammatory response. However, the role of AhR in IL-10 production by inflammatory …
inflammatory response. However, the role of AhR in IL-10 production by inflammatory …
Lipid rafts sense and direct electric field-induced migration
B Lin, S Tsao, A Chen, SK Hu… - Proceedings of the …, 2017 - National Acad Sciences
Endogenous electric fields (EFs) are involved in developmental regulation and wound
healing. Although the phenomenon is known for more than a century, it is not clear how cells …
healing. Although the phenomenon is known for more than a century, it is not clear how cells …
The AhR‐SRC axis as a therapeutic vulnerability in BRAFi‐resistant melanoma
A Paris, N Tardif, FM Baietti, C Berra… - EMBO Molecular …, 2022 - embopress.org
The nongenetic mechanisms required to control tumor phenotypic plasticity and shape drug‐
resistance remain unclear. We show here that the Aryl hydrocarbon Receptor (AhR) …
resistance remain unclear. We show here that the Aryl hydrocarbon Receptor (AhR) …
The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis
M Contador-Troca, A Alvarez-Barrientos… - …, 2013 - academic.oup.com
Melanoma is a highly metastatic and malignant skin cancer having poor rates of patient
survival. Since the incidence of melanoma is steadily increasing in the population, finding …
survival. Since the incidence of melanoma is steadily increasing in the population, finding …
Aryl hydrocarbon receptor promotes liver polyploidization and inhibits PI3K, ERK, and Wnt/β-catenin signaling
N Moreno-Marín, JM Merino, A Alvarez-Barrientos… - IScience, 2018 - cell.com
Aryl hydrocarbon receptor (AhR) deficiency alters tissue homeostasis. However, how AhR
regulates organ maturation and differentiation remains mostly unknown. Liver differentiation …
regulates organ maturation and differentiation remains mostly unknown. Liver differentiation …
Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis
M Contador-Troca, A Alvarez-Barrientos, JM Merino… - Molecular cancer, 2015 - Springer
Abstract Background The dioxin (AhR) receptor can have oncogenic or tumor suppressor
activities depending on the phenotype of the target cell. We have shown that AhR …
activities depending on the phenotype of the target cell. We have shown that AhR …
Environmental ligands of the aryl hydrocarbon receptor and their effects in models of adult liver progenitor cells
J Vondráček, M Machala - Stem Cells International, 2016 - Wiley Online Library
The toxicity of environmental and dietary ligands of the aryl hydrocarbon receptor (AhR) in
mature liver parenchymal cells is well appreciated, while considerably less attention has …
mature liver parenchymal cells is well appreciated, while considerably less attention has …
Indoxyl 3-sulfate stimulates Th17 differentiation enhancing phosphorylation of c-Src and STAT3 to worsen experimental autoimmune encephalomyelitis
SJ Hwang, YJ Hwang, MO Yun, JH Kim, GS Oh… - Toxicology Letters, 2013 - Elsevier
Although AhR activation regulates CD4T cell differentiation, how it works has yet to be
elucidated. In the present study, using in vitro Th17 differentiation model, we examined …
elucidated. In the present study, using in vitro Th17 differentiation model, we examined …