Zinc is known to be indispensable to growth and development and transmission of the
genetic message. It does this through a remarkable mosaic of zinc binding motifs that …

The number of zinc enzymes for which detailed structural and mechanistic data, including
high resolution crystal structures, are available is increasing rapidly. The new finding …

Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells
and nonprostatic solid tumor neovasculature and is a target for anticancer imaging and …

Clostridium botulinum neurotoxins are among the most potent toxins to humans. The crystal
structures of intact C. botulinum neurotoxin type B (BoNT/B) and its complex with …

Membrane‐bound glutamate carboxypeptidase II (GCPII) is a zinc metalloenzyme that
catalyzes the hydrolysis of the neurotransmitter N‐acetyl‐l‐aspartyl‐l‐glutamate (NAAG) to …

Metalloaminopeptidases remove the N-terminal amino acid from proteins or small
oligopeptides. This modification or truncation process can occur either co-translationally or …

In living organisms it is necessary to be able to perform countless hydrolysis reactions
efficiently and, above all, selectively to sustain thousands, maybe even millions, of critical …

The structure of the zinc-dependent β-lactamase II from Bacillus cereus has been
determined at 1.9 Å resolution in a crystal form with two molecules in the asymmetric unit …

Carnosinases are Xaa-His dipeptidases that play diverse functions throughout all kingdoms
of life. Human isoforms of carnosinase (CN1 and CN2) under appropriate conditions …

The selective hydrolysis of the extremely stable phosphoester, peptide and ester bonds of
molecules by bio-inspired metal-based catalysts (metallohydrolases) is required in a wide …