Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

A hypothetical model of Alzheimer's disease (AD) as a uniquely human brain disorder
rooted in its exceptional process of myelination is presented. Cortical regions with the most …

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by central nervous
(CNS) demyelination resulting in axonal injury and neurological deficits. Essentially, MS is …

Opioid overdose is the leading cause of death for Americans 25 to 64 years of age, and
opioid use disorder affects> 2 million Americans. The epidemiology of opioid-associated out …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal transcription factor in the defence
against oxidative stress. Here we provide evidence that activation of the Nrf2 pathway …

Abstract TRPML1 (mucolipin 1, also known as MCOLN1) is predicted to be an intracellular
late endosomal and lysosomal ion channel protein that belongs to the mucolipin subfamily …

MRI and histological studies have shown global alterations in iron levels in the brains of
patients with multiple sclerosis (MS), including increases in the iron stored by macrophages …

Astrocytes, once believed to serve only as “glue” for the structural support of neurons, have
been demonstrated to serve critical functions for the maintenance and protection of neurons …

Dysfunction of iron metabolism, which includes its uptake, storage, and release, plays a key
role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's …

Mitochondria are essential to maintain neuronal viability. In addition to the generation of ATP
and maintenance of calcium homeostasis, the effective delivery of mitochondria to the …