Molecularly stimuli-responsive self-assembled peptide nanoparticles for targeted imaging and therapy

Y Zhou, Q Li, Y Wu, X Li, Y Zhou, Z Wang, H Liang… - ACS …, 2023 - ACS Publications
Self-assembly has emerged as an extensively used method for constructing biomaterials
with sizes ranging from nanometers to micrometers. Peptides have been extensively …

NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications

C Jiang, H Huang, X Kang, L Yang, Z Xi… - Chemical Society …, 2021 - pubs.rsc.org
Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …

Intra-Lysosomal Peptide Assembly for the High Selectivity Index against Cancer

B Jana, S Jin, EM Go, Y Cho, D Kim, S Kim… - Journal of the …, 2023 - ACS Publications
Lysosomes remain powerful organelles and important targets for cancer therapy because
cancer cell proliferation is greatly dependent on effective lysosomal function. Recent studies …

Synthesizing biomaterials in living organisms

X Zhang, J Wang, Y Zhang, Z Yang, J Gao… - Chemical Society …, 2023 - pubs.rsc.org
Living organisms fabricate biomacromolecules such as DNA, RNA, and proteins by the self-
assembly process. The research on the mechanism of biomacromolecule formation also …

A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly

SY Qin, JQ Feng, YJ Cheng, WL Liu, AQ Zhang… - Coordination Chemistry …, 2024 - Elsevier
In the last few decades, we have witnessed the great advances of molecular self-assembly
in biomedical applications. Among the building blocks for molecular self-assembly, peptide …

Supramolecular self‐assembly in living cells

M Dergham, S Lin, J Geng - Angewandte Chemie, 2022 - Wiley Online Library
Supramolecular interactions rely on non‐covalent forces, such as hydrophobic effects,
hydrogen‐bonding, and electrostatic interactions, which govern many intracellular biological …

Intranuclear nanoribbons for selective killing of osteosarcoma cells

S Liu, Q Zhang, H He, M Yi, W Tan… - Angewandte Chemie …, 2022 - Wiley Online Library
Herein, we show intranuclear nanoribbons formed upon dephosphorylation of leucine‐rich L‐
or D‐phosphopeptide catalyzed by alkaline phosphatase (ALP) to selectively kill …

Enzymatically forming intranuclear peptide assemblies for selectively killing human induced pluripotent stem cells

S Liu, Q Zhang, AN Shy, M Yi, H He… - Journal of the American …, 2021 - ACS Publications
Tumorigenic risk of undifferentiated human induced pluripotent stem cells (iPSCs), being a
major obstacle for clinical application of iPSCs, requires novel approaches for selectively …

Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems

Y Wang, J Zhan, J Huang, X Wang… - Interdisciplinary …, 2023 - Wiley Online Library
Dynamic‐responsive self‐assembly is the process of ordered supramolecular structure
formation or reversible decomposition from building blocks. This process is driven by non …

Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells

S Kim, JB Chae, D Kim, CW Park, Y Sim… - Journal of the …, 2023 - ACS Publications
Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic
strategy for various age-related diseases. Most senolytics target antiapoptotic proteins …