The use of single‐cell RNA sequencing (scRNA‐seq) in microglial research is increasing
rapidly. The basic workflow of this approach consists of isolating single cells, followed by …

The relationship between the evolutionary history and the differentiation of Bregs is still not
clear. Bregs were demonstrated to possess a regulatory effect on B cells. Various subsets of …

Understanding the evolution of interleukins and interleukin receptors is essential to control
the function of CD4+ T cells in various pathologies. Numerous aspects of CD4+ T cells' …

Infiltration of the endothelial layer of the blood-brain barrier by leukocytes plays a critical role
in health and disease. When passing through the endothelial layer during the diapedesis …

Regulatory T cell (Treg) suppression of conventional T cells is a central mechanism that
ensures immune system homeostasis. The exact time point of Treg emergence is still …

Biased agonism, the ability of agonists to differentially activate downstream signaling
pathways by stabilizing specific receptor conformations, is a key issue for G protein-coupled …

Repurposing drugs to target M1 macrophages inflammatory response in depression
constitutes a bright alternative for commonly used antidepressants. Depression is a …

Simple Summary Understanding the evolutionary association between immune cells and
the blood–brain barrier (BBB) is vital to develop therapeutic approaches. In Drosophila, glial …

The MCC family of genes plays a role in colorectal cancer development through various
immunological pathways, including the Th17/Treg axis. We have previously shown that …

Abstract Autoimmune Regulator 1 (AIRE1) and Forebrain Embryonic Zinc Finger-Like
Protein 2 (FEZF2) play pivotal roles in orchestrating the expression of tissue-restricted …