The functional capabilities of skeletal muscle are strongly correlated with its well-arranged
microstructure, consisting of parallelly aligned myotubes. In case of extensive muscle loss …

Tendinopathy is a multi-faceted pathology characterized by alterations in tendon
microstructure, cellularity and collagen composition. Challenged by the possibility of …

Viscoelastic hydrogels can enhance 3D cell migration and proliferation due to the faster
stress relaxation promoting the arrangement of the cellular microenvironment. However …

Tendon and ligament injuries caused by trauma and degenerative diseases are frequent
and affect diverse groups of the population. Such injuries reduce musculoskeletal …

Highlights•The study of multifactorial diseases needs in vitro models involving complex
interactions.•Model complexity can be of biological or technological nature.•Final …

Over the past years, 3D in vitro models have been widely employed in the regenerative
medicine field. Among them, organ-on-a-chip technology has the potential to elucidate …

From the discovery of ATP and motor proteins to synaptic neurotransmitters and growth
factor control of cell differentiation, skeletal muscle has provided an extreme model system …

Bioprinting is a promising technology focusing on tissue manufacturing, whose vital problem
is the precise assembly of multiple materials. As the primary solution, the extrusion-based …

The field of biomedical design and manufacturing has been rapidly evolving, with implants
and grafts featuring complex 3D design constraints and materials distributions. By …

Recent years have seen development of more complex models of human skeletal muscle
that mimic physiological subtleties of native tissue, including the neuromuscular junction …