Blood GFAP as an emerging biomarker in brain and spinal cord disorders
Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The
introduction of highly sensitive immunoassays led to a rapid increase in the number of …
introduction of highly sensitive immunoassays led to a rapid increase in the number of …
Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues
Background The use of blood biomarkers after mild traumatic brain injury (mTBI) has been
widely studied. We have identified eight unresolved issues related to the use of five …
widely studied. We have identified eight unresolved issues related to the use of five …
Evaluation of glial and neuronal blood biomarkers compared with clinical decision rules in assessing the need for computed tomography in patients with mild …
L Papa, JG Ladde, JF O'Brien, JG Thundiyil… - JAMA Network …, 2022 - jamanetwork.com
Importance In 2018, the combination of glial fibrillary acidic protein (GFAP) and ubiquitin C-
terminal hydrolase (UCH-L1) levels became the first US Food and Drug Administration …
terminal hydrolase (UCH-L1) levels became the first US Food and Drug Administration …
Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury
Z Mi, SH Graham - Ageing research reviews, 2023 - Elsevier
UCHL1 is a multifunctional protein expressed at high concentrations in neurons in the brain
and spinal cord. UCHL1 plays important roles in regulating the level of cellular free ubiquitin …
and spinal cord. UCHL1 plays important roles in regulating the level of cellular free ubiquitin …
Thorough overview of ubiquitin C‐terminal hydrolase‐L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration …
Traumatic brain injury (TBI) is a major cause of mortality and morbidity affecting all ages. It
remains to be a diagnostic and therapeutic challenge, in which, to date, there is no Food and …
remains to be a diagnostic and therapeutic challenge, in which, to date, there is no Food and …
The known unknowns: an overview of the state of blood-based protein biomarkers of mild traumatic brain injury
Blood-based protein biomarkers have revolutionized several fields of medicine by enabling
molecular level diagnosis, as well as monitoring disease progression and treatment efficacy …
molecular level diagnosis, as well as monitoring disease progression and treatment efficacy …
Sex differences in time course and diagnostic accuracy of GFAP and UCH-L1 in trauma patients with mild traumatic brain injury
Abstract Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal hydrolase (UCH-L1)
have been FDA-approved for clinical use in mild and moderate traumatic brain injury (TBI) …
have been FDA-approved for clinical use in mild and moderate traumatic brain injury (TBI) …
Inflammatory biomarkers of traumatic brain injury
NH Johnson, R Hadad, RR Taylor, J Rodríguez Pilar… - Pharmaceuticals, 2022 - mdpi.com
Traumatic brain injury (TBI) has a complex pathology in which the initial injury releases
damage associated proteins that exacerbate the neuroinflammatory response during the …
damage associated proteins that exacerbate the neuroinflammatory response during the …
Peripheral blood and salivary biomarkers of blood–brain barrier permeability and neuronal damage: clinical and applied concepts
Within the neurovascular unit (NVU), the blood–brain barrier (BBB) operates as a key
cerebrovascular interface, dynamically insulating the brain parenchyma from peripheral …
cerebrovascular interface, dynamically insulating the brain parenchyma from peripheral …
One-year prospective study of plasma biomarkers from CNS in patients with mild traumatic brain injury
GJB Clarke, T Skandsen, H Zetterberg… - Frontiers in …, 2021 - frontiersin.org
Objective: To investigate the longitudinal evolution of three blood biomarkers: neurofilament
light (NFL), glial fibrillary acidic protein (GFAP) and tau, in out-patients and hospitalized …
light (NFL), glial fibrillary acidic protein (GFAP) and tau, in out-patients and hospitalized …