TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

Abstract p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite
for cancer development. The p53 gene is the most frequently mutated gene in human …

Colorectal cancer (CRC) is one of the most common malignancies with high prevalence and
low 5-year survival. CRC is a heterogeneous disease with a complex, genetic and …

Since a decade, there has been a strong consumer demand for more natural products. This
has augmented inclination towards substitution of synthetic colorants with natural pigments …

The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis …

Prodigiosin, a natural red pigment produced by numerous bacterial species, has exhibited
promising anticancer activity; however, the molecular mechanisms of action of prodigiosin …

Accumulated evidence indicates that autophagy is a response of cancer cells to various anti-
cancer therapies. Autophagy is designated as programmed cell death type II, and is …

Cancer stands in the frontline among leading killers worldwide and the annual mortality rate
is expected to reach 16.4 million by 2040. Humans suffer from about 200 different types of …

Simple Summary The tumor suppressor protein p53 is frequently mutated in human cancers,
and its reactivation represents an encouraging hope for precision anticancer therapy …