The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

The beating heart possesses intrinsic ability to adapt cardiac output to changes in
mechanical load. The century-old Frank-Starling law and Anrep effect have documented that …

We report that in heart cells, physiologic stretch rapidly activates reduced-form nicotinamide
adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) to produce reactive oxygen …

Cardiac optical mapping has proven to be a powerful technology for studying cardiovascular
function and disease. The development and scientific impact of this methodology are well …

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …

In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress
transduced by the microtubule network elicits reactive oxygen species. X-ROS tunes Ca2+ …

Cardiac hypertrophy is initiated as an adaptive response to sustained overload but
progresses pathologically as heart failure ensues. Here we report that genetic loss of APJ, a …