OBJECTIVE: To summarize the role of reactive oxygen species (ROS) in the
pathophysiology of human reproduction. DESIGN: Review of literature. SETTING: Fertility …

The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

Spermatozoa are physiologically exposed to reactive oxygen species (ROS) that play a
pivotal role on several sperm functions through activation of different intracellular …

The onset of clinical assisted reproduction, a quarter of a century ago, required the isolation
of motile spermatozoa. As the indication of assisted reproduction shifted from mere …

The objective of this study was to determine the incidence of DNA fragmentation in human
sperm, and to correlate any detected DNA damage with semen analysis parameters and …

In human in-vitro fertilization (IVF)-embryo transfer, the in-vitro culture environment differs
from in-vivo conditions in that the oxygen concentration is higher, and in such conditions the …

Apoptosis is a universal and continuous event during tissue development, restoration,
repair, and regeneration. Mounting evidence has demonstrated that apoptosis is essential …

The objective of this study was to evaluate the effect of the generation of reactive oxygen
species (ROS) on the integrity of the DNA of human spermatozoa, and to determine if …

OBJECTIVE: The manipulation of gametes and embryos in an in vitro environment when
performing assisted reproductive techniques (ART) carries the risk of exposure of these cells …

Assisted conception is a useful methodology for detecting disturbances in clinical outcome,
meiotic maturation, and genetic integrity of human gametes. Germinal cells are vulnerable to …