Regulation and metabolic functions of mTORC1 and mTORC2
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
The role of ubiquitination and deubiquitination in cancer metabolism
T Sun, Z Liu, Q Yang - Molecular cancer, 2020 - Springer
Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
Metabolomics for investigating physiological and pathophysiological processes
DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
X Li, M Wenes, P Romero, SCC Huang… - Nature reviews Clinical …, 2019 - nature.com
The development of immunotherapies over the past decade has resulted in a paradigm shift
in the treatment of cancer. However, the majority of patients do not benefit from …
in the treatment of cancer. However, the majority of patients do not benefit from …
2-Oxoglutarate-dependent dioxygenases in cancer
JA Losman, P Koivunen, WG Kaelin Jr - Nature Reviews Cancer, 2020 - nature.com
Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …
Coupling Krebs cycle metabolites to signalling in immunity and cancer
Metabolic reprogramming has become a key focus for both immunologists and cancer
biologists, with exciting advances providing new insights into the mechanisms underlying …
biologists, with exciting advances providing new insights into the mechanisms underlying …
Altered cellular metabolism in gliomas—An emerging landscape of actionable co-dependency targets
Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …
technological advances, new insights into the molecular mechanisms underlying glioma …
A pan-cancer proteogenomic atlas of PI3K/AKT/mTOR pathway alterations
Y Zhang, PKS Ng, M Kucherlapati, F Chen, Y Liu… - Cancer cell, 2017 - cell.com
Molecular alterations involving the PI3K/AKT/mTOR pathway (including mutation, copy
number, protein, or RNA) were examined across 11,219 human cancers representing 32 …
number, protein, or RNA) were examined across 11,219 human cancers representing 32 …
[HTML][HTML] Biological role and therapeutic potential of IDH mutations in cancer
Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2
(IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins …
(IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins …
Signaling pathways in brain tumors and therapeutic interventions
S Li, C Wang, J Chen, Y Lan, W Zhang… - … and Targeted Therapy, 2023 - nature.com
Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …
Although there are few therapeutic options for brain tumors, enhanced biological …