The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …

Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

The primary cilium is an antenna-like organelle assembled on most types of quiescent and
differentiated mammalian cells. This immotile structure is essential for interpreting …

Primary cilia are microtubule-based organelles that extend from the apical surface of most
mammalian cells, forming when the basal body (derived from the mother centriole) docks at …

Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently,
actin cytoskeleton destabilization has been recognized as a dominant inducer of …

Nephronophthisis (NPHP) is a renal ciliopathy and an autosomal recessive cause of cystic
kidney disease, renal fibrosis, and end-stage renal failure, affecting children and young …

Bardet–Biedl Syndrome is a rare non-motile primary ciliopathy with multisystem involvement
and autosomal recessive inheritance. The clinical picture is extremely polymorphic. The …

Cerebral cortical development involves a complex series of highly regulated steps to
generate the laminated structure of the adult neocortex. Neuronal migration is a key part of …

Fetal lung underdevelopment, also known as pulmonary hypoplasia, is characterized by
decreased lung growth and maturation. The most common birth defect found in babies with …

Primary cilia are sensory, antennae‐like organelles present on the surface of many cell
types. They have been involved in a variety of diseases collectively termed ciliopathies. As …