Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …

The plasma membrane protein Orai forms the pore of the calcium release–activated calcium
(CRAC) channel and generates sustained cytosolic calcium signals when triggered by …

Regions of close apposition between two organelles, often referred to as membrane contact
sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle …

Membrane-bound organelles are a wonderful evolutionary acquisition of the eukaryotic cell,
allowing the segregation of sometimes incompatible biochemical reactions into specific …

Lymphocyte function is regulated by a network of ion channels and transporters in the
plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations …

Ca2+ entry into cells of the peripheral immune system occurs through highly Ca2+-selective
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …

Store-operated calcium entry is a central mechanism in cellular calcium signalling and in
maintaining cellular calcium balance. This review traces the history of research on store …

Store operated calcium entry (SOCE) is a principal cellular process by which cells regulate
basal calcium, refill intracellular Ca 2+ stores, and execute a wide range of specialized …

Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …