Machine learning for multi-omics data integration in cancer

Z Cai, RC Poulos, J Liu, Q Zhong - Iscience, 2022 - cell.com
Multi-omics data analysis is an important aspect of cancer molecular biology studies and
has led to ground-breaking discoveries. Many efforts have been made to develop machine …

Proteome discoverer—a community enhanced data processing suite for protein informatics

BC Orsburn - Proteomes, 2021 - mdpi.com
Proteomics researchers today face an interesting challenge: how to choose among the
dozens of data processing and analysis pipelines available for converting tandem mass …

Global detection of human variants and isoforms by deep proteome sequencing

P Sinitcyn, AL Richards, RJ Weatheritt… - Nature …, 2023 - nature.com
An average shotgun proteomics experiment detects approximately 10,000 human proteins
from a single sample. However, individual proteins are typically identified by peptide …

[HTML][HTML] Pan-cancer proteomic map of 949 human cell lines

E Gonçalves, RC Poulos, Z Cai, S Barthorpe… - Cancer Cell, 2022 - cell.com
The proteome provides unique insights into disease biology beyond the genome and
transcriptome. A lack of large proteomic datasets has restricted the identification of new …

[HTML][HTML] Quantitative proteomics of the cancer cell line encyclopedia

DP Nusinow, J Szpyt, M Ghandi, CM Rose… - Cell, 2020 - cell.com
Proteins are essential agents of biological processes. To date, large-scale profiling of cell
line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily …

Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities

S Vasaikar, C Huang, X Wang, VA Petyuk, SR Savage… - Cell, 2019 - cell.com
We performed the first proteogenomic study on a prospectively collected colon cancer
cohort. Comparative proteomic and phosphoproteomic analysis of paired tumor and normal …

The target landscape of clinical kinase drugs

S Klaeger, S Heinzlmeir, M Wilhelm, H Polzer, B Vick… - Science, 2017 - science.org
INTRODUCTION Molecularly targeted drugs such as imatinib and crizotinib have
revolutionized the treatment of certain blood and lung cancers because of their remarkable …

On the dependency of cellular protein levels on mRNA abundance

Y Liu, A Beyer, R Aebersold - Cell, 2016 - cell.com
The question of how genomic information is expressed to determine phenotypes is of central
importance for basic and translational life science research and has been studied by …

Data-independent acquisition mass spectrometry (DIA-MS) for proteomic applications in oncology

L Krasny, PH Huang - Molecular omics, 2021 - pubs.rsc.org
Data-independent acquisition mass spectrometry (DIA-MS) is a next generation proteomic
methodology that generates permanent digital proteome maps offering highly reproducible …

Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences

C Manzoni, DA Kia, J Vandrovcova… - Briefings in …, 2018 - academic.oup.com
Advances in the technologies and informatics used to generate and process large biological
data sets (omics data) are promoting a critical shift in the study of biomedical sciences. While …