The multifunctional zinc‐finger protein CCCTC‐binding factor (CTCF) is a very strong
candidate for the role of coordinating the expression level of coding sequences with their …

Hi-C is a commonly used technology in 3D genomics which can depict global chromatin
interactions across eukaryotic genome. Integrating with different datasets, it can also be …

Distal myopathies represent a heterogeneous group of inherited skeletal muscle disorders.
One type of adult-onset, progressive autosomal-dominant distal myopathy, frequently …

Human karyotype is usually studied by classical cytogenetic (banding) techniques. To
perform it, one has to obtain metaphase chromosomes of mitotic cells. This leads to the …

There is rapidly growing evidence that folding of the chromatin fibre inside the interphase
nucleus has an important role in the regulation of gene expression. In particular, the …

The mechanisms underlying gravity perception in mammalian cells are unknown. We have
recently discovered that the transcriptome of cells in the immune system, which is the most …

In eukaryotic cells the genome is highly spatially organized. Functional relevance of higher
order genome organization is implied by the fact that specific genes, and even whole …

The nucleolus produces the large polycistronic transcript (47S precursor) containing the
18S, 5.8 S and 28S rRNA sequences and hosts most of the nuclear steps of pre-rRNA …

In diplotene oocyte nuclei of all vertebrate species, except mammals, chromosomes lack
interchromosomal contacts and chromatin is linearly compartmentalized into distinct …

The Brain-Derived Neurotrophic Factor is one of the most important trophic proteins in the
brain. The role of this growth factor in neuronal plasticity, in health and disease, has been …