Background Extracellular matrix (ECM) is a dynamic and complex environment
characterized by biophysical, mechanical and biochemical properties specific for each …

Neutrophils are produced in the bone marrow from stem cells that proliferate and
differentiate to mature neutrophils fully equipped with an armory of granules. These contain …

Quantitative assays for human DNA and mRNA were used to examine the paradox that
intravenously (iv) infused human multipotent stromal cells (hMSCs) can enhance tissue …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

Multipotent mesenchymal stromal cells (MSCs) are tested in numerous clinical trials.
Questions have been raised concerning fate and function of these therapeutic cells after …

Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …

Extracellular matrix can influence stem cell choices, such as self‐renewal, quiescence,
migration, proliferation, phenotype maintenance, differentiation, or apoptosis. Three aspects …

Stem cells have the capacity for self-renewal and differentiation into specialized cells that
form and repopulated all tissues and organs, from conception to adult life. Depending on …

Stem cell self-renewal is tightly controlled by the concerted action of stem cell-intrinsic
factors and signals within the niche. Niche signals often function within a short range …

Regulation of stem cells in adult tissues is a key determinant of how well an organism can
respond to the stresses of physiological challenge and disease. This is particularly true of …