Metallodrugs are unique: Opportunities and challenges of discovery and development
EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …
are not accessible to purely organic compounds. At least 10 metals are essential for human …
Oxidative stress in cancer therapy: friend or enemy?
M Azmanova, A Pitto‐Barry - Chembiochem, 2022 - Wiley Online Library
Excessive cellular oxidative stress is widely perceived as a key factor in pathophysiological
conditions and cancer development. Healthy cells use several mechanisms to maintain …
conditions and cancer development. Healthy cells use several mechanisms to maintain …
[HTML][HTML] Advances in the design of organometallic anticancer complexes
P Zhang, PJ Sadler - Journal of Organometallic Chemistry, 2017 - Elsevier
Organometallic complexes containing ligands such as CO, carbenes, alkyls, phenyls, π-
bound alkynes, alkenes, cyclopentadienyls and arenes possess properties which have often …
bound alkynes, alkenes, cyclopentadienyls and arenes possess properties which have often …
Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium
The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …
investigation of coordination and organometallic complexes of alternative metal centers for …
Single-cell chemistry of photoactivatable platinum anticancer complexes
EM Bolitho, C Sanchez-Cano, H Shi… - Journal of the …, 2021 - ACS Publications
The Pt (IV) prodrug trans, trans, trans-[Pt (pyridine) 2 (N3) 2 (OH) 2](Pt1) and its coumarin
derivative trans, trans, trans-[Pt (pyridine) 2 (N3) 2 (OH)(coumarin-3-carboxylate)](Pt2) are …
derivative trans, trans, trans-[Pt (pyridine) 2 (N3) 2 (OH)(coumarin-3-carboxylate)](Pt2) are …
X-ray-based techniques to study the nano–bio interface
X-ray-based analytics are routinely applied in many fields, including physics, chemistry,
materials science, and engineering. The full potential of such techniques in the life sciences …
materials science, and engineering. The full potential of such techniques in the life sciences …
X‐ray elemental mapping techniques for elucidating the ecophysiology of hyperaccumulator plants
A van Der Ent, WJ Przybyłowicz, MD de Jonge… - New …, 2018 - Wiley Online Library
Contents Summary 432 I. Introduction 433 II. Preparation of plant samples for X‐ray micro‐
analysis 433 III. X‐ray elemental mapping techniques 438 IV. X‐ray data analysis 442 V …
analysis 433 III. X‐ray elemental mapping techniques 438 IV. X‐ray data analysis 442 V …
A comparative study of ultrasmall calcium carbonate nanoparticles for targeting and imaging atherosclerotic plaque
L Martínez-Parra, M Piñol-Cancer, C Sanchez-Cano… - ACS …, 2023 - ACS Publications
Atherosclerosis is a complex disease that can lead to life-threatening events, such as
myocardial infarction and ischemic stroke. Despite the severity of this disease, diagnosing …
myocardial infarction and ischemic stroke. Despite the severity of this disease, diagnosing …
Subcellular chemical imaging: new avenues in cell biology
To better understand the physiology and acclimation capability of the cell, one of the great
challenges of the future is to access the interior of a cell and unveil its chemical landscape …
challenges of the future is to access the interior of a cell and unveil its chemical landscape …
Half-sandwich iridium and ruthenium complexes: effective tracking in cells and anticancer studies
JJ Li, L Guo, Z Tian, S Zhang, Z Xu, Y Han, R Li… - Inorganic …, 2018 - ACS Publications
Half-sandwich metal-based anticancer complexes suffer from uncertain targets and
mechanisms of action. Herein we report the observation of the images of half-sandwich …
mechanisms of action. Herein we report the observation of the images of half-sandwich …