Abstract Purpose of Review Juvenile-onset systemic lupus erythematosus ((j) SLE) is an
autoimmune/inflammatory disease that results in significant damage and disability. When …

Systemic lupus erythematosus (SLE) is an autoimmune disease with manifestations derived
from the involvement of multiple organs including the kidneys, joints, nervous system and …

Studies over the past decade have demonstrated a key role for pattern recognition receptors
in the activation of autoreactive B cells. Self reactive B cells that manage to escape negative …

Autoimmune and immunodeficiency diseases are outcomes of a dysfunctional immune
system and represent 2 sides of the same coin. Multiple single-gene defects have been …

Objective The Sjögren's International Collaborative Clinical Alliance (SICCA) is an
international data registry and biorepository derived from a multisite observational study of …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease and occurs
worldwide in both children and adults. The estimated annual incidence among children is …

In a genome-wide association study (GWAS) of individuals of European ancestry afflicted
with systemic lupus erythematosus (SLE) the extensive utilization of imputation, step-wise …

The past decade has seen an explosion in the use of DNA-based microarrays. These
techniques permit assessment of RNA abundance on a genome-wide scale. Medical …

Tuberculosis (TB) caused by Mycobacterium bovis is a re-emerging disease of livestock that
is of major economic importance worldwide, as well as being a zoonotic risk. There is …

The pleiotropic cytokine interferon alpha is involved in multiple aspects of lupus etiology and
pathogenesis. Interferon alpha is important under normal circumstances for antiviral …